‘Grey’s Anatomy’ 300th episode flashback: Remember when Katherine Heigl screamed ‘S***!’ after winning Emmy? [WATCH]

Not many people predicted that Katherine Heigl (“Grey’s Anatomy”) would win an Emmy in 2007, including most notably Heigl herself. “S***!” she screamed after being named Best Drama Supporting Actress for her role as intern Izzie Stevens on ABC’s medical drama, which this week celebrates its landmark 300th episode. Watch Heigl’s memorable Emmys acceptance speech above.

Heigl’s nominated co-stars — Sandra Oh as Cristina Yang and Chandra Wilson as Miranda Bailey — cheered her on as she made her way to the Emmy podium. “Thanks for gettin’ my name right!” Heigl joked to the cast of “Entourage” and Eva Longoria, who presented her with her trophy. “My own mother told me I didn’t have a shot in hell of winning tonight, so I really don’t have anything prepared. This is my dream come true.”

Infamously, this was Heigl’s first and last Emmy nomination. The very next year she chose to withdraw her name from Emmy consideration, telling Gold Derby in 2008, “I did not feel that I was given the material this season to warrant an Emmy nomination and in an effort to maintain the integrity of the academy organization, I withdrew my name from contention. In addition, I did not want to potentially take away an opportunity from an actress who was given such materials.” She was never nominated again.

Oh won a Golden Globe for her role in 2006 and also earned five Emmy nominations (2005-2009), while Wilson was a four-time Emmy nominee (2006-2009). Series star Ellen Pompeo was never embraced by the Emmys for playing Meredith Grey, though the show did win Best Drama Casting in 2006. In addition to Heigl’s acting victory, guest star Loretta Devine prevailed for her recurring role as Adele Webber in 2011.

The show itself earned a pair of Best Drama Series bids at the Emmys in 2006 and 2007, losing to “24” and “The Sopranos,” respectively. Despite never taking home that top prize, “Grey’s Anatomy” is getting the last laugh commercially as Thursday’s 300th episode is truly a monumental achievement in television. “Grey’s Anatomy” was created by television titan Shonda Rhimes, who has since left ABC for Netflix.

Heigl and Oh join a long line of cast members who have scrubbed out of “Grey’s Anatomy,” including most notably Patrick Dempsey as Derek Shepherd, T.R. Knight as George O’Malley, Isaiah Washington as Preston Burke, Kate Walsh as Addison Montgomery-Shepherd, Sara Ramirez as Callie Torres and most recently Martin Henderson as Nathan Riggs.

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