Nixon plays Vivian Dearing, a brilliant and demanding professor in research treatments to save her own life. She has one previous Tony Award win in two career nominations.
Lavin plays Rita Lyons, a headstrong mother who gathers her adult children at the side of their ailing father. She has one previous Tony Award win in five career nominations.
Arianda plays Vanda, a needy and crude actress trying to dominate her new director. She has one previous Tony Award nomination.
Channing plays Polly Wyeth, a woman whose daughter is about to publish a memoir full of family secrets. She has one previous Tony Award win in six career nominations.