Bialik plays Dr. Amy Farrah Fowler, a socially awkward neurobiologist. This is her first Emmy nomination.
Wever plays Zoey Barkow, an inexperienced yet jubilant nurse. This is her first Emmy nomination.
Joosten plays Karen McCluskey, the elderly and nosy neighbor in a suburban neighborhood. She has two Emmy wins in four career nominations.
Wiig plays various characters on the variety series. She has five career Emmy nominations.
Bowen plays Claire Dunphy, a perfectionistic homemaker with three children. She has one Emmy win in three career nominations.
Vergara plays Gloria Pritchett, a passionate and protective Colombian wife and mother. She has three career Emmy nominations.