Kazee plays Guy, an Irish musician drawn romantically to a Czech immigrant. He has no previous Tony Award nominations.
Raines plays Benjamin Stone, a handsome and successful husband of a former chorus girl. He has no previous Tony Award nominations.
Fleeshman plays Sam Wheat, a young man who is murdered but finds himself trapped as a ghost trying to communicate with his girlfriend. He has no previous Tony Award nominations.
Carney plays Peter Parker, a young man bitten by a spider who turns into the super hero Spider-Man. He has no previous Tony Award nominations.
Esparza plays Jonas Nightingale, a part-time reverend and full-time con artist inviting a small town to his revival. He has four previous Tony Award nominations.
Nolan plays Jesus Christ, the savior in his final days leading up to his crucifixion. He has no previous Tony Award nominations.
Lewis plays Porgy, a crippled man on Catfish Row in Charleston, South Carolina. He has no previous Tony Award nominations.
Broderick plays Jimmy Winter, a Jazz Age playboy who gets involved with bootleggers and gold diggers. He has two previous Tony Award wins in three career nominations.
Segarra plays Mick, a basketball player at Athens University. He has no previous Tony Award nominations.
Jordan plays Jack Kelly, a newsboy who dreams of a better life far from the hardships of the streets. He has no previous Tony Award nominations.
Jordan plays Clyde Barrow, a criminal on the run from the law in Depression-era Texas. He has no previous Tony Award nominations.
Parrish plays Jesus Christ, the savior celebrating with his disciples interpreted through the Gospel of Matthew. He has no previous Tony Award nominations.
Connick plays Dr. Mark Bruckner, a psychiatrist who begins to fall in love with one of his patients. He has two previous Tony Award nominations.
Burstein plays Buddy Plummer, a salesman in his early fifties and husband of a former chorus girl. He has two previous Tony Award nominations.