Dunham plays Hannah, a single girl in New York City. This is her first Emmy acting nomination with nods this year also for producing, directing, and writing.
Louis-Dreyfus plays Selina Meyer, a former United States Senator who becomes Vice-President. She has two Emmy wins in 13 career nominations.
Deschanel plays Jess Day, an energetic young teacher who leaves her cheating boyfriend and moves into an apartment with three men to start a new life. This is her first Emmy nomination.
McCarthy plays Molly Flynn, an overweight fourth-grade school teacher who is dating a hefty police officer. She has one Emmy win in three career nominations.
Poehler plays Leslie Knope, a spirited woman who loves her small home town and her job at the parks department. She has seven career Emmy nominations.
Fey plays Liz Lemon, the head writer and producer of the fictional "TGS" variety series on NBC. She has seven Emmy wins in 23 career nominations.
Falco plays Jackie Peyton, a drug-addicted nurse who struggles to balance her work life with her family. She has four Emmy wins in 10 career nominations.